南京大学理学博士，教授，硕士研究生导师，美国内布拉斯加大学医学中心巴菲特癌症中心访问学者；长期从事中药提取物、化学药等抗癌药效、药理、毒理以及肿瘤发生、发展机制研究，研究方向有中药有效成分/化学药抗肿瘤药效药理、免疫调节抗肿瘤药效药理、肿瘤发生发展机制。
教育与研究经历：
1. 2004年6月获福建农林大学理学硕士学位
2. 2015年6月获南京大学理学博士
3. 2019.4-2020.7美国内布拉斯加大学医学中心巴菲特癌症中心访问学者
研究领域：
生物医药与肿瘤发生发展分子机理
学术成果：
1.Lai Chen, Pan Xu, Qiuping Xiao, Liling Chen, Shanshan Li, Jimo Jian, Youbao Zhong*. Sunitinib malate inhibits intestinal tumor development in male Apc(Min/+) mice by down-regulating inflammation-related factors with suppressing β-cateinin/c-Myc pathway and re-balancing Bcl-6 and Caspase-3. Int Immunopharmacol, 2020: p. 107128.
2.Ping Wan, Sumei Zheng, Lai Chen, Dou Wang, Ting Liao, Xueming Yan and Xiaoji Wang. The Exocyst Component Sec3 Controls Egg Chamber Development Through Notch During Drosophila Oogenesis. Front. Physiol. 10:345. 2019.
3.Youbao Zhong, Shanshan Li, Liling Chen, Zhiyong Liu, Xiaoquan Luo, Peng Xu, Lai Chen * . In vivo toxicity of solasonine and its effects on cyp450 family gene expression in livers of male mice from four strains, Toxins, 10, 487. 2018.
4.Xu Shen, Xiaohan Sun, Bing Sun, Tao Li, Guoliang Wu, Yuantao Li, Lai Chen, Qingxin Liu, Meng Cui, Zizhang Zhou* . ARRDC3 suppresses colorectal cancer progression through destabilizing the oncoprotein YAP: Febs Letters, v. 592, p. 599-609. 2018.
5.Qi Xiao, Guoxin Zhang, Huijuan Wang, Lai Chen, Shuangshuang Lu, Dejing Pan, Geng Liu* , Zhongzhou Yang* . A p53-based genetic tracing system to follow postnatal cardiomyocyte expansion in heart regeneration. Development 2017 144: 580-589. 2017.
6.Guoxin Zhang, Yinyin Xie, Ying Zhou, Cong Xiang, Lai Chen, Chenxi Zhang, Xiaoshuang Hou, Jiong Chen, Hui Zong, and Geng Liu* . p53 pathway is involved in cell competition during mouse embryogenesis: Proc Natl Acad Sci U S A, v. 114, p. 498-503. 2017.
7.Lai Chen#, Guoxin Zhang#, Yin Zhou, Chenxi Zhang, Yinyin Xie, Cong Xiang, Xieyan He, Qin Zhang and Geng Liu*. BAC transgenic mice provide evidence that p53 expression is highly regulated in vivo. Cell Death Dis, 2015. 6(9): p. e1878.
