博士毕业于湖南大学,目前主要开展癌症病因学、天然化合物抗癌有效成分的筛选以及分子作用机制研究。主持两项国家自然科学基金项目,多项省部级课题,并发表SCI论文30多篇。
研究领域:
癌症病因学、癌症转移分子机制、天然化合物抗癌有效成分的筛选以及疗效分析
学术成果:
1. WRAP53通过USP11介导NF-κB信号转导通路调控促进非小细胞肺癌细胞增殖的分子机制研究,国家自然科学基金(81402304),主持,已结题;
2. p65调控WDR79转录促进肺癌发展和耐药作用及机制,国家自然科学基金(81860492),主持,在研;
3. WDR79 促进肺癌非小细胞增殖的分子机制研究,江西省自然科学基金青年基金(20161BAB215221),主持,结题;
4. 根癌农杆菌介导拟南芥FERONIA的柑橘遗传转化及培育,江西省科技计划项目一般项目(20171BBF60070),主持
1. Chao Yang, Hui Chen, Hongli Chen, Balian Zhong, Xuzhong Luo and Jiong Chun *. Antioxidant and Anticancer Activities of Essential Oil from Gannan Navel Orange Peel. Molecules 2017, 22(8), 1391
2. Zhou H#, Yang C#, Chen H, Li X, Li Y, Fan X. A simple G-quadruplex molecular beacon-based biosensor for highly selective detection of microRNA. Biosens Bioelectron. 2017 Jan 15;87:552-557. (Co-First author)
3. Sun Y#, Yang C#, Chen J, Song X, Li Z, Duan M, Li J, Hu X, Wu K, Yan G, Yang C, Liu J, Tan W, Ye M. Overexpression of WDR79 in non-small cell lung cancer is linked to tumour progression. J Cell Mol Med. 2016.4.01,20(4):698~709 (Co-First author)
4. Yang Chao#, Chen Hui#, Tan Guixiang, Gao Wei, Cheng Liang, Jiang Xia, Yu Li, *Tan Yongjun. FOXM1 promotes the epithelial to mesenchymal transition by stimulating the transcription of Slug in human breast cancer. Cancer Letters. 2013, 340(1):104-112.
5. Yang C#, Chen H#, Yu L, Shan L, Xie L, Hu J, Chen T, *Tan Y. Inhibition of FOXM1 transcription factor suppresses cell proliferation and tumor growth of breast cancer, CANCER GENE THERAPY. 2013, 20(2):117-124.
6. Chen Hui#, Yang Chao#, Yu Li, Xie Li, Hu Jun, Zeng Liang, Tan Yongjun. Adenovirus-mediated RNA interference targeting FOXM1 transcription factor suppresses cell proliferation and tumor growth of nasopharyngeal carcinoma. Journal of Gene Medicine. 2012, 14: 231-240.(Co-First author)